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Sci Signal. 2010 Oct 12;3(143):pt1. doi: 10.1126/scisignal.3143pt1.

Hormone resistance at the clinical level.

Author information

1
Division of Pediatric Endocrinology, Meyer Children's Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel. z_hochberg@rambam.health.gov.il

Abstract

This presentation introduces clinical aspects of hormone resistance through a number of case studies that illustrate how molecular defects at various steps in hormone production, signaling, or responsiveness can produce disease in humans. The presentation also shows how careful phenotyping of such patients has triggered decades of translational research.

PMID:
20940426
DOI:
10.1126/scisignal.3143pt1
[Indexed for MEDLINE]

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