Format

Send to

Choose Destination
See comment in PubMed Commons below
Dement Geriatr Cogn Disord. 2010;30(4):344-51. doi: 10.1159/000318836. Epub 2010 Oct 12.

Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment.

Author information

1
Institute for Health and Aging, University of California, San Francisco, USA. Julene.Johnson@ucsf.edu

Abstract

BACKGROUND/AIMS:

There are few studies that evaluate the clinical outcomes of individuals with non-amnestic mild cognitive impairment (MCI). The purpose of this study was to evaluate baseline predictors of clinical progression after 2 years for patients with dysexecutive MCI (dMCI), a single-domain non-amnestic MCI subgroup.

METHODS:

We evaluated clinical progression in a sample of 31 older adults with dMCI. Clinical progression was defined as a worsening on the Clinical Dementia Rating sum of boxes at the 2-year visit, whereas patients were classified as stable if the score did not worsen over 2 years. We compared baseline brain MRI, neuropsychological tests, and health risk factors.

RESULTS:

Twelve individuals with dMCI progressed clinically, and 19 individuals remained stable over 2 years. Compared to the stable dMCI patients, the dMCI patients who progressed showed brain atrophy in the bilateral insula and left lateral temporal lobe on MRI. dMCI patients who progressed were also older, had lower baseline performance on category fluency and a spatial location task, and reported fewer dysexecutive symptoms. Health risk factors, except hypertension, did not differ between groups.

CONCLUSION:

The results suggest that dMCI patients who progress relatively quickly over 2 years may have unique clinical and brain MRI features.

PMID:
20938178
PMCID:
PMC2975734
DOI:
10.1159/000318836
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Support Center