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Arch Neurol. 2010 Oct;67(10):1181-4. doi: 10.1001/archneurol.2010.258.

Beclin 1 complex in autophagy and Alzheimer disease.

Author information

1
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5235, USA.

Abstract

Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases. It also provides a brief overview of the existing pharmacological interventions available to modulate autophagy activity in mammalian cells.

PMID:
20937944
DOI:
10.1001/archneurol.2010.258
[Indexed for MEDLINE]

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