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Biochem Biophys Res Commun. 2010 Nov 12;402(2):297-300. doi: 10.1016/j.bbrc.2010.10.018. Epub 2010 Oct 19.

Neuronal activity and the expression of clathrin-assembly protein AP180.

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1
Laboratory of Neurosciences, NIA/NIH, Baltimore, MD 21224, United States.

Abstract

The clathrin-assembly protein AP180 is known to promote the assembly of clathrin-coated vesicles in the neuron. However, it is unknown whether the expression of AP180 is influenced by neuronal activity. In this study, we report that chronic depolarization results in a reduction of AP180 from hippocampal neurons, while acute depolarization causes a dispersed synaptic distribution of AP180. Activity-induced effects are observed only for AP180, but not for the structurally-related clathrin-assembly proteins CALM, epsin1, or HIP1. These findings suggest that AP180 levels and synaptic distribution are highly sensitive to neuronal activity.

PMID:
20937255
PMCID:
PMC2981697
DOI:
10.1016/j.bbrc.2010.10.018
[Indexed for MEDLINE]
Free PMC Article
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