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Int J Tuberc Lung Dis. 2010 Nov;14(11):1430-5.

Latent tuberculosis infection among close contacts of multidrug-resistant tuberculosis patients in central Taiwan.

Author information

1
Department of Tuberculosis, Changhua Hospital, Taiwan Department of Health, Changhua City, Taiwan. hiwen@mail.chhw.doh.gov.tw

Abstract

SETTING:

Both the tuberculin skin test (TST) and the QuantiFERON®-TB Gold In-Tube test (QFT-GIT) may be used to detect Mycobacterium tuberculosis infection. A positive reaction to either test can indicate latent tuberculosis infection (LTBI). These tests can be used to study the rate of infection in contacts of multidrug-resistant tuberculosis (MDR-TB) patients.

OBJECTIVE:

To evaluate the transmission status of MDR-TB patients in Taiwan by examining their close contacts and to compare the efficiency of TST and QFT-GIT.

DESIGN:

Chest radiographs, TST and QFT-GIT were performed in household contacts of confirmed MDR-TB patients to determine their infection status.

RESULTS:

A total of 78 close contacts of confirmed MDR-TB patients were included in the study. The majority of the MDR-TB patients were parents of the close contacts and lived in the same building; 46% of the subjects were TST-positive and 19% were QFT-GIT-positive, indicating LTBI that was likely to develop into active MDR-TB. There was a lack of consistency between TST and QFT-GIT results in subjects with previous bacille Calmette-Guérin vaccination.

CONCLUSION:

Household contacts of MDR-TB patients are likely to develop LTBI; thus, follow-up and monitoring are mandatory to provide treatment and reduce the occurrence of active infection.

PMID:
20937183
[Indexed for MEDLINE]

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