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Aging Male. 2011 Mar;14(1):42-7. doi: 10.3109/13685538.2010.518179. Epub 2010 Oct 12.

Gonadal status and physical performance in older men.

Author information

1
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy. marcellomaggio2001@yahoo.it

Abstract

OBJECTIVE:

To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants.

METHODS:

The study included 455 ≥ 65 year older men of InCHIANTI study, Italy, with complete data on testosterone levels, hand grip strength, cross-sectional muscle area (CSMA), short physical performance battery (SPPB). Linear models were used to test the relationship between gonadal status and determinants of physical performance.

RESULTS:

Three different groups of older men were created: (1) severely hypogonadal (N=23), total testosterone levels ≤ 230 ng /dl; (2) moderately hypogonadal (N=88), total testosterone >230 and < 350 ng/dl) and (3) eugonadal (N=344), testosterone levels ≥ 350 ng/dl. With increased severity of hypogonadal status, participants were significantly older while their BMI was substantially similar. In the age and BMI adjusted analysis, there was a significant difference in haemoglobin levels, hand grip strength and SPPB score (p for trend < 0.001) among three groups, with severely hypogonadal men having lower values of haemoglobin, muscle strength and physical performance. We found no association between testosterone group assignment and calf muscle mass and 4 m walking speed. In the multivariate analysis grip strength (p for trend = 0.004) and haemoglobin (p for trend < 0.0001) but not SPPB and other determinants of physical performance were significantly different between the three groups.

CONCLUSIONS:

In older men, gonadal status is independently associated with some determinants (haemoglobin and muscle strength) of physical performance.

PMID:
20937007
PMCID:
PMC3142745
DOI:
10.3109/13685538.2010.518179
[Indexed for MEDLINE]
Free PMC Article

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