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J Nucleic Acids. 2010 Sep 22;2010. pii: 389129. doi: 10.4061/2010/389129.

Nonhomologous DNA end joining in cell-free extracts.

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1
Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.

Abstract

Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems.

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