Send to

Choose Destination
See comment in PubMed Commons below
J Nucleic Acids. 2010 Sep 22;2010. pii: 389129. doi: 10.4061/2010/389129.

Nonhomologous DNA end joining in cell-free extracts.

Author information

Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.


Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center