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Autophagy. 2011 Jan;7(1):118-22. doi: 10.1083/jcb.200803137. Epub 2011 Jan 1.

What is the advantage of a transient precursor in autophagosome biogenesis?

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Babraham Institute, Babraham, Cambridge, UK.


We have recently proposed that some autophagosomes are formed within omegasomes, membrane sites connected to the endoplasmic reticulum and enriched in phosphatidylinositol 3-phosphate. In order to understand if there is any biological advantage to having such a precursor in autophagosome biogenesis, we generated a simple computer program that simulates omegasome and autophagosome formation under a variety of conditions. We concluded from running this simulation that having a transient precursor permits a bigger dynamic range of the autophagic response and allows a more efficient approach to steady state after autophagy stimulation.

[Indexed for MEDLINE]

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