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J Neurol Neurosurg Psychiatry. 2011 May;82(5):569-73. doi: 10.1136/jnnp.2010.217489. Epub 2010 Oct 9.

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients.

Author information

1
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK.

Abstract

BACKGROUND:

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.

METHODS:

To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.

RESULTS:

The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.

CONCLUSION:

The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.

PMID:
20935326
PMCID:
PMC3072048
DOI:
10.1136/jnnp.2010.217489
[Indexed for MEDLINE]
Free PMC Article
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