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J Immunol. 2010 Nov 1;185(9):4988-92. doi: 10.4049/jimmunol.1002042. Epub 2010 Oct 8.

Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

Author information

1
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

CD8(+) T cells responding to intracellular infection give rise to cellular progeny that become terminally differentiated effector cells and self-renewing memory cells. T-bet and eomesodermin (Eomes) are key transcription factors of cytotoxic lymphocyte lineages. We show in this study that CD8(+) T cells lacking Eomes compete poorly in contributing to the pool of Ag-specific central memory cells. Eomes-deficient CD8(+) T cells undergo primary clonal expansion but are defective in long-term survival, populating the bone marrow niche and re-expanding postrechallenge. The phenotype of Eomes-deficient CD8(+) T cells supports the hypothesis that T-bet and Eomes can act redundantly to induce effector functions, but can also act to reciprocally promote terminal differentiation versus self-renewal of Ag-specific memory cells.

PMID:
20935204
PMCID:
PMC2975552
DOI:
10.4049/jimmunol.1002042
[Indexed for MEDLINE]
Free PMC Article
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