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Semin Cancer Biol. 2010 Oct;20(5):304-11. doi: 10.1016/j.semcancer.2010.10.003. Epub 2010 Oct 8.

Mutator phenotypes due to DNA replication infidelity.

Author information

1
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Abstract

This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in processes that determine DNA replication fidelity can confer strong mutator phenotypes whose specificity can help determine the molecular nature of the defect.

PMID:
20934516
PMCID:
PMC3087159
DOI:
10.1016/j.semcancer.2010.10.003
[Indexed for MEDLINE]
Free PMC Article

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