Format

Send to

Choose Destination
Curr Opin Microbiol. 2011 Feb;14(1):16-23. doi: 10.1016/j.mib.2010.08.014. Epub 2010 Oct 8.

Shigella deploy multiple countermeasures against host innate immune responses.

Author information

1
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Abstract

Although the intestinal epithelium is equipped with multiple defense systems that sense bacterial components, transmit alarms to the immune system, clear the bacteria, and renew the injured epithelial lining, mucosal bacterial pathogens are capable of efficiently colonizing the intestinal epithelium, because they have evolved systems that modulate the inflammatory and immune responses of the host and exploit the harmful environments as replicative niches. In this review we highlight current topics concerning Shigella's tactics that interfere with the innate immune systems.

PMID:
20934372
DOI:
10.1016/j.mib.2010.08.014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center