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Trends Cogn Sci. 2010 Nov;14(11):506-15. doi: 10.1016/j.tics.2010.09.001.

The functional role of cross-frequency coupling.

Author information

1
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. rcanolty@gmail.com

Abstract

Recent studies suggest that cross-frequency coupling (CFC) might play a functional role in neuronal computation, communication and learning. In particular, the strength of phase-amplitude CFC differs across brain areas in a task-relevant manner, changes quickly in response to sensory, motor and cognitive events, and correlates with performance in learning tasks. Importantly, whereas high-frequency brain activity reflects local domains of cortical processing, low-frequency brain rhythms are dynamically entrained across distributed brain regions by both external sensory input and internal cognitive events. CFC might thus serve as a mechanism to transfer information from large-scale brain networks operating at behavioral timescales to the fast, local cortical processing required for effective computation and synaptic modification, thus integrating functional systems across multiple spatiotemporal scales.

PMID:
20932795
PMCID:
PMC3359652
DOI:
10.1016/j.tics.2010.09.001
[Indexed for MEDLINE]
Free PMC Article

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