Format

Send to

Choose Destination
West Indian Med J. 2010 Jan;59(1):3-6.

Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats.

Author information

1
Department of Pharmacology, Kasturba Medical College, Manipal-576104, Karnataka, India.

Abstract

OBJECTIVE:

Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken.

MATERIALS AND METHODS:

The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study.

RESULTS:

Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg.

CONCLUSION:

Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.

PMID:
20931905
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center