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Turk J Gastroenterol. 2010 Sep;21(3):270-4.

Fulminant hepatic failure and serum phosphorus levels in children from the western part of Turkey.

Author information

1
Department of Pediatrics, Division of Pediatric Gastroeenterology, Hepatology and Nutrition, Dokuz Eylül University, School of Medicine, İzmir. yesimzaferozturk@gmail.com

Abstract

BACKGROUND/AIMS:

Clinical and laboratory predictors of recovery in children with fulminant hepatic failure are limited. Recently, hypophosphatemia has been reported as a laboratory indicator of recovering liver function in children with fulminant hepatic failure . We aimed to determine the incidence of hypophosphatemia and its association with clinical outcome in children in our center with fulminant hepatic failure.

METHODS:

We analyzed 21 children who had been diagnosed with fulminant hepatic failure. Laboratory findings were recorded from admission date until the patient spontaneously recovered, underwent orthotopic liver transplantation or died.

RESULTS:

Eight patients (38%) died, 6 (28.6%) underwent orthotopic liver transplantation, and 7 (33.3%) recovered without orthotopic liver transplantation. We identified hypophosphatemia in 57.1% of children with fulminant hepatic failure. Serum phosphorus levels were significantly lower in patients who recovered than in the orthotopic liver transplantation+death group. The presence of encephalopathy was determined at a much lower rate in the recovery group than in the orthotopic liver transplantation+death group. Serum phosphorus concentration ≥2.9 mg/dl and presence of encephalopathy were identified as independent risk factors for mortality.

CONCLUSIONS:

Hypophosphatemia can be identified as a marker of recovery in children with fulminant hepatic failure. Presence of encephalopathy and a serum phosphorus level ≥2.9 mg/dl appear to indicate a poor prognosis in children with fulminant hepatic failure.

PMID:
20931431
[Indexed for MEDLINE]
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