Send to

Choose Destination
J Genet Couns. 2011 Feb;20(1):5-19. doi: 10.1007/s10897-010-9325-x. Epub 2010 Oct 8.

Genetic counseling considerations in the evaluation of families for Lynch syndrome--a review.

Author information

Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.


Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center