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EMBO Rep. 2010 Nov;11(11):834-40. doi: 10.1038/embor.2010.160. Epub 2010 Oct 8.

MAPK signalling in cellular metabolism: stress or wellness?

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1
Department of Biology, Institute of Cell Biology, ETH Zurich, Hönggerberg Campus, Switzerland.

Abstract

Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intracellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.

PMID:
20930846
PMCID:
PMC2966959
DOI:
10.1038/embor.2010.160
[Indexed for MEDLINE]
Free PMC Article
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