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EMBO Rep. 2010 Nov;11(11):890-5. doi: 10.1038/embor.2010.144. Epub 2010 Oct 8.

Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis.

Author information

1
Department of Medical Biochemistry & Biophysics, Umeå University, Umeå, Sweden.

Abstract

Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice.

PMID:
20930845
PMCID:
PMC2966953
DOI:
10.1038/embor.2010.144
[Indexed for MEDLINE]
Free PMC Article

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