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J Cell Sci. 2010 Oct 15;123(Pt 20):3447-55. doi: 10.1242/jcs.063727.

Post-translational modifications of microtubules.

Author information

1
Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Science, 02-093 Warsaw, Poland.

Erratum in

  • J Cell Sci. 2011 Jan 1;124(Pt 1):154.

Abstract

Microtubules--polymers of tubulin--perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.

PMID:
20930140
PMCID:
PMC2951466
DOI:
10.1242/jcs.063727
[Indexed for MEDLINE]
Free PMC Article

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