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Mol Cell Proteomics. 2011 Jan;10(1):M110.000976. doi: 10.1074/mcp.M110.000976. Epub 2010 Oct 7.

Uncovering the human methyltransferasome.

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1
Department of Chemistry and Biochemistry and Molecular Biology Institute, UCLA, Los Angeles, California 90095-1570, USA.

Abstract

We present a comprehensive analysis of the human methyltransferasome. Primary sequences, predicted secondary structures, and solved crystal structures of known methyltransferases were analyzed by hidden Markov models, Fisher-based statistical matrices, and fold recognition prediction-based threading algorithms to create a model, or profile, of each methyltransferase superfamily. These profiles were used to scan the human proteome database and detect novel methyltransferases. 208 proteins in the human genome are now identified as known or putative methyltransferases, including 38 proteins that were not annotated previously. To date, 30% of these proteins have been linked to disease states. Possible substrates of methylation for all of the SET domain and SPOUT methyltransferases as well as 100 of the 131 seven-β-strand methyltransferases were surmised from sequence similarity clusters based on alignments of the substrate-specific domains.

PMID:
20930037
PMCID:
PMC3013446
DOI:
10.1074/mcp.M110.000976
[Indexed for MEDLINE]
Free PMC Article
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