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Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2680-4. doi: 10.1158/1055-9965.EPI-10-0585.

Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.

Author information

1
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

Abstract

BACKGROUND:

Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known.

METHODS:

Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.

RESULTS:

We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).

CONCLUSION:

We did not find any associations between food or nutrient intake and CLL/SLL.

IMPACT:

Our large prospective study indicates that diet may not play a role in CLL/SLL development.

PMID:
20929883
PMCID:
PMC3501724
DOI:
10.1158/1055-9965.EPI-10-0585
[Indexed for MEDLINE]
Free PMC Article

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