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Arch Virol. 2011 Jan;156(1):121-4. doi: 10.1007/s00705-010-0818-6. Epub 2010 Oct 7.

The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective.

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Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.


To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.

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