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PLoS Negl Trop Dis. 2010 Sep 28;4(9):e744. doi: 10.1371/journal.pntd.0000744.

Mycobacterium africanum--review of an important cause of human tuberculosis in West Africa.

Author information

1
MRC Laboratories, Bacterial Diseases Programme, Fajara, The Gambia. bdejong@itg.be

Abstract

Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.

PMID:
20927191
PMCID:
PMC2946903
DOI:
10.1371/journal.pntd.0000744
[Indexed for MEDLINE]
Free PMC Article

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