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Osteoporos Int. 2011 Jun;22(6):1765-71. doi: 10.1007/s00198-010-1392-1. Epub 2010 Oct 6.

Parity and risk of hip fracture in postmenopausal women.

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  • 1Division of Welfare and Health Promotion, National Institute for Health and Welfare, Peltolantie 3, 20720 Turku, Finland. maarit.kauppi@thl.fi

Abstract

Hip fracture risk was assessed according to parity among postmenopausal women. Compared with nulliparous women, the fracture risk was lower in women with three or more births.

INTRODUCTION:

Parity was assessed for long-term prediction of hip fracture in postmenopausal women.

METHODS:

Postmenopausal women (n= 2,028) aged 45 or over with no history of hip fracture were studied. From 1978 to 1980, all of them had participated in a comprehensive health survey based on a nationally representative population sample. Emerging cases of hip fracture were identified from the National Hospital Discharge Register during a follow-up period extending up to 17 years.

RESULTS:

The risk of hip fracture was lower among parous women compared with nulliparous women. The model adjusted for age showed a significant inverse association between parity as a continuous variable and the risk of hip fracture [RR = 0.74; 95% confidence interval (CI), 0.61-0.90] per an increment of one standard deviation (2.4 births). Adjusted for age, menopausal age, level of education, body mass index, vitamin D status, alcohol consumption, smoking history, leisure time physical activity, and self-rated health, the relative risk was 0.50 (95% CI, 0.32-0.79) for women with three or more births and 0.85 (95% CI, 0.55-1.32) for women with one to two births as compared with nulliparous women.

CONCLUSION:

Parity, three or more births in particular, predicts a lowered risk of hip fracture in the long run.

PMID:
20924749
DOI:
10.1007/s00198-010-1392-1
[PubMed - indexed for MEDLINE]
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