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J Mol Microbiol Biotechnol. 2010;19(3):147-51. doi: 10.1159/000321501. Epub 2010 Oct 6.

Streptomyces coelicolor A3(2) produces a new yellow pigment associated with the polyketide synthase Cpk.

Author information

1
Department of Microbiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. pawlik@iitd.pan.wroc.pl

Abstract

Streptomyces coelicolor A3(2) is an extensively studied model organism for the genetic studies of Streptomycetes - a genus known for the production of a vast number of bioactive compounds and complex regulatory networks controlling morphological differentiation and secondary metabolites production. We present the discovery of a presumptive product of the Cpk polyketide synthase. We have found that on the rich medium without glucose S. coelicolor A3(2) produces a yellow compound secreted into the medium. We have proved by complementation that production of the observed yellow pigment is dependent on cpk gene cluster previously described as cryptic type I polyketide synthase cluster. The pigment production depends on the medium composition, does not occur in the presence of glucose, and requires high density of spore suspension used for inoculation.

PMID:
20924201
DOI:
10.1159/000321501
[Indexed for MEDLINE]

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