Send to

Choose Destination
J Oral Pathol Med. 2010 Nov;39(10):735-40. doi: 10.1111/j.1600-0714.2010.00947.x. Epub 2010 Oct 4.

Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study.

Author information

Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Avda. Marques de los Velez s ⁄ n, Murcia, Spain.



  Different treatments have been used in application to symptomatic oral lichen planus (OLP), with variable results, perhaps caused by the refractory nature of the disease. The objective of this study was to evaluate the efficacy of the topical application of aloe vera (AV) in OLP compared with placebo.


A total of 64 patients with OLP were randomized in a double-blind study to either AV (32 patients) or placebo (32 patients), at a dose of 0.4 ml (70% concentration) three times a day. A Visual Analog Scale was used for rating pain, with the application of a clinical scale for scoring the lesions, the Oral Health Impact Profile 49 (OHIP-49), and the Hospital Anxiety-Depression (HAD) scale. The patients were evaluated after 6 and 12 weeks.


No statistically significant differences were recorded between both groups in relation to pain after 6 and 12 weeks. In the AV group, complete pain remission was achieved in 31.2% of the cases after 6 weeks, and in 61% after 12 weeks. In the placebo group, these percentages were 17.2% and 41.6%, respectively. There were no adverse effects in any of the groups. In relation to quality of life, significant differences were observed between the two groups in the psychological disability domain and total OHIP-49 score.


The topical application of AV improves the total quality of life score in patients with OLP.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center