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Org Lett. 2010 Nov 5;12(21):5060-3. doi: 10.1021/ol1023135.

Copper-mediated oxidative trifluoromethylation of boronic acids.

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  • 1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Abstract

A copper-mediated oxidative cross-coupling of aryl- and alkenylboronic acids with (trifluoromethyl)trimethylsilane (Me(3)SiCF(3)) under mild conditions has been developed. This method allows a wide range of functional group tolerant trifluoromethylated arenes and alkenes to be easily prepared. This oxidative trifluoromethylation has the potential to introduce trifluoromethyl groups into advanced, highly functionalized organic molecules.

PMID:
20923196
DOI:
10.1021/ol1023135
[PubMed - indexed for MEDLINE]
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