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J Nat Prod. 2010 Oct 22;73(10):1694-700. doi: 10.1021/np100461t. Epub 2010 Oct 5.

Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides.

Author information

1
Department of Chemistry, University of Puerto Rico, P.O. Box 23346, UPR Station, San Juan, Puerto Rico 00931-3346, USA.

Abstract

Two new five-membered-ring polyketide endoperoxides, epiplakinic acid F methyl ester (1) and epiplakinidioic acid (3), and a peroxide-lactone, plakortolide J (2), were isolated from the Puerto Rican sponge Plakortis halichondrioides, along with two previously reported cyclic peroxides, 4 and 5. The structures of the new metabolites were determined by spectroscopic and chemical analyses. The absolute stereostructures of 1, 2, and 5 were determined by degradation reactions followed by application of Kishi's method for the assignment of absolute configuration of alcohols. Biological screening of cycloperoxides 1-5 and semisynthetic analogues 7-12 for cytotoxic activity against various human tumor cell lines revealed that compounds 3, 4, and 11 are very active. Upon assaying for antimalarial and antitubercular activity, some of the compounds tested showed strong activity against the pathogenic microbes Plasmodium falciparum and Mycobacterium tuberculosis.

PMID:
20923180
PMCID:
PMC3036788
DOI:
10.1021/np100461t
[Indexed for MEDLINE]
Free PMC Article

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