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Circ J. 2010 Nov;74(11):2403-9. Epub 2010 Sep 29.

Cardiac abnormalities in primary hyperoxaluria.

Author information

1
Division of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ, USA. mookadam.farouk@mayo.edu

Abstract

BACKGROUND:

In patients with primary hyperoxaluria (PH), oxalate overproduction can result in recurrent urolithiasis and nephrocalcinosis, which in some cases results in a progressive decline in renal function, oxalate retention, and systemic oxalosis involving bone, retina, arterial media, peripheral nerves, skin, and heart. Oxalosis involving the myocardium or conduction system can potentially lead to heart failure and fatal arrhythmias.

METHODS AND RESULTS:

A retrospective review of our institution's database was conducted for all patients with a confirmed diagnosis of PH between 1/1948 and 1/2006 (n=103). Electrocardiogram (ECG) and echocardiography were used to identify cardiac abnormalities. Ninety-three patients fulfilled the inclusion criteria, 58% were male. Mean follow-up was 11.9 (median 8.8) years. In 38 patients who received an ECG or echocardiography, 31 were found to have any cardiac abnormalities. Cardiac findings correlated with decline in renal function.

CONCLUSIONS:

Our data suggests that physicians caring for patients with PH should pay close attention to cardiac status, especially if renal function is impaired.

PMID:
20921818
PMCID:
PMC5929473
[Indexed for MEDLINE]
Free PMC Article

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