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FEBS Lett. 2010 Dec 15;584(24):4872-7. doi: 10.1016/j.febslet.2010.09.045. Epub 2010 Oct 12.

The dissociation activation model of B cell antigen receptor triggering.

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Centre of Biological Signalling Studies BIOSS, University Freiburg, Freiburg, Germany.


To detect its cognate antigen, each B lymphocyte contains up to 120000 B cell antigen receptor (BCR) complexes on its cell surface. How these abundant receptors remain silent on resting B cells and how they can be activated by a molecularly diverse set of ligands is poorly understood. The antigen-specific activation of the BCR is currently explained by the cross-linking model (CLM). This model predicts that the many BCR complexes on the surface of a B cell are dispersed signalling-inert monomers and that it is BCR dimerization that initiates signalling from the receptor. The finding that the BCR forms auto-inhibited oligomers on the surface of resting B cells falsifies these predictions of the CLM. We propose the dissociation activation model (DAM), which fits better with the existing body of experimental data.

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