Format

Send to

Choose Destination
See comment in PubMed Commons below
Nutr J. 2010 Sep 28;9:41. doi: 10.1186/1475-2891-9-41.

Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia.

Author information

1
South East Asia Minister of Education Organization Tropical Medicine, Regional Center for Community Nutrition, University of Indonesia, Jl, Salemba Raya no 6, Jakarta Pusat 10420, Indonesia. tpakasi_commed@fk.ui.ac.id

Abstract

BACKGROUND:

A previous study showed that combination of zinc and vitamin A reduced sputum conversion time in pulmonary tuberculosis (TB) patients.

OBJECTIVE:

We studied the efficacy of which single micronutrient contributed more to the sputum conversion time.

METHODS:

In a double-blind randomized community trial, newly sputum smear positive pulmonary TB patients were assigned randomly to receive zinc, vitamin A, zinc + vitamin A or placebo on top of TB treatment. Patients were asked to deliver their sputum on weekly basis to measure positivity of the bacteria. Nutritional status, chest x-ray, hemoglobin, C-reactive protein (CRP), retinol and zinc level were examined prior to, after 2 and 6 months of treatment.

RESULTS:

Initially, 300 patients were enrolled, and 255 finished the treatment. Most patients were severely malnourished (mean BMI 16.5 ± 2.2 Kg/m2). Patients in the zinc + vitamin A group showed earlier sputum conversion time (mean 1.9 weeks) compared with that in the other groups; however the difference was not significant. Also, no benefit could be demonstrated of any of the used supplementations on clinical, nutritional, chest x-ray, or laboratory findings.

CONCLUSIONS:

This study among severely malnourished TB patients, did not confirm that single or combined supplementation of zinc and vitamin A significantly reduced sputum conversion time or had other significant benefit.

PMID:
20920186
PMCID:
PMC2957385
DOI:
10.1186/1475-2891-9-41
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center