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Antioxid Redox Signal. 2011 Sep 1;15(5):1449-61. doi: 10.1089/ars.2010.3647. Epub 2011 Apr 15.

"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.

Author information

1
Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Abstract

Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.

PMID:
20919941
PMCID:
PMC3144441
DOI:
10.1089/ars.2010.3647
[Indexed for MEDLINE]
Free PMC Article

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