Format

Send to

Choose Destination
See comment in PubMed Commons below
Adv Exp Med Biol. 2010;688:217-31.

Roles for sphingolipids in Saccharomyces cerevisiae.

Author information

1
Department of Molecular and Cellular Biochemistry, Lucille P. Markey Cancer Center, University of Kentucky College of Medicine, 741 S. Limestone St., BBSRB, 8173, Lexington, Kentucky 40536-0509, USA. bobd@uky.edu

Abstract

Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.

PMID:
20919657
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center