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Curr Gastroenterol Rep. 2010 Dec;12(6):513-21. doi: 10.1007/s11894-010-0148-6.

Intraepithelial lymphocytes: to serve and protect.

Author information

1
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. bsheridan@uchc.edu

Abstract

The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical.

PMID:
20890736
PMCID:
PMC3224371
DOI:
10.1007/s11894-010-0148-6
[Indexed for MEDLINE]
Free PMC Article

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