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Opt Lett. 2010 Oct 1;35(19):3189-91. doi: 10.1364/OL.35.003189.

Full-field time-resolved fluorescence tomography of small animals.

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Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.


In this experimental investigation, we explore the feasibility of using wide-field illumination for time-resolved fluorescence molecular tomography. The performance of wide-field patterns with a time-resolved imaging platform is investigated in vitro and in a small animal model. A Monte Carlo-based forward model is employed to reconstruct fluorescence yield based on time-gated datasets. An improvement in resolution and quantification when using the time-gate data type compared to the commonly used cw data type is demonstrated in vitro. Furthermore, the feasibility of wide-field strategies for fluorescence preclinical applications is established by an accurate localization of a fluorescent inclusion implanted in the chest cavity of a murine model.

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