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Nat Neurosci. 2010 Nov;13(11):1351-3. doi: 10.1038/nn.2642. Epub 2010 Oct 3.

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice.

Author information

1
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.

Abstract

DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.

PMID:
20890295
DOI:
10.1038/nn.2642
[Indexed for MEDLINE]

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