Format

Send to

Choose Destination
Cell Adh Migr. 2010 Oct-Dec;4(4):609-21.

Factors controlling cardiac neural crest cell migration.

Author information

1
Department of Pediatrics, Duke University, Durham, NC, USA. mlkirby@duke.edu

Abstract

Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continue migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration, and condensation of these cells. This review elucidates what is currently known about these factors.

PMID:
20890117
PMCID:
PMC3011257
DOI:
10.4161/cam.4.4.13489
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center