Format

Send to

Choose Destination
Trends Biochem Sci. 2011 Mar;36(3):141-50. doi: 10.1016/j.tibs.2010.08.004. Epub 2010 Oct 15.

BUB1 and BUBR1: multifaceted kinases of the cell cycle.

Author information

1
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA. Cambridge, England. victor@cryst.bioc.cam.ac.uk

Abstract

The multidomain protein kinases BUB1 and BUBR1 (Mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (SAC). This evolutionarily conserved and essential self-monitoring system of the eukaryotic cell cycle ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. Despite their amino acid sequence conservation and similar domain organization, BUB1 and BUBR1 perform different functions in the SAC. Recent structural information provides crucial molecular insights into the regulation and recognition of BUB1 and BUBR1, and a solid foundation to dissect the roles of these proteins in the control of chromosome segregation in normal and oncogenic cells.

PMID:
20888775
PMCID:
PMC3061984
DOI:
10.1016/j.tibs.2010.08.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center