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Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):297-301. doi: 10.1016/j.colsurfb.2010.08.045. Epub 2010 Sep 9.

Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles.

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College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.


Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407±50nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8-16% and 44-83%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities.

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