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Immunity. 2010 Oct 29;33(4):607-19. doi: 10.1016/j.immuni.2010.09.009. Epub 2010 Sep 30.

MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.

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1
Division of Biology, California Institute of Technology, 330 Braun, 1200 E. California Boulevard, Pasadena, CA 91125, USA.

Abstract

Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammatory disease. Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155(-/-) mice were highly resistant to experimental autoimmune encephalomyelitis (EAE). miR-155 functions in the hematopoietic compartment to promote the development of inflammatory T cells including the T helper 17 (Th17) cell and Th1 cell subsets. Furthermore, the major contribution of miR-155 to EAE was CD4(+) T cell intrinsic, whereas miR-155 was also required for optimum dendritic cell production of cytokines that promoted Th17 cell formation. Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders.

PMID:
20888269
PMCID:
PMC2966521
DOI:
10.1016/j.immuni.2010.09.009
[Indexed for MEDLINE]
Free PMC Article
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