Format

Send to

Choose Destination
Breast Cancer Res. 2010;12(5):313. doi: 10.1186/bcr2631. Epub 2010 Sep 22.

Mammary stem cells and cancer: roles of Wnt signaling in plain view.

Author information

1
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.

Abstract

The likely roles of Wnt signaling in regulating mammary stem cell behavior have been much discussed, in part because they may underlie the oncogenic effects of Wnt signaling in mammary tissue. Two recent papers add important data to this field. One tests directly the effects of purified Wnt protein on mouse mammary stem cells in culture and finds a specific increase in the proportion of cells with self-renewing stem cell phenotypes. The second identifies a novel target gene of canonical Wnt signaling that may be expressed in stem cells and is induced in both mouse and human mammary tumors associated with Wnt pathway activation.

PMID:
20887643
PMCID:
PMC3096951
DOI:
10.1186/bcr2631
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center