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Annu Rev Med. 2011;62:347-60. doi: 10.1146/annurev-med-050109-142444.

Hepcidin and disorders of iron metabolism.

Author information

1
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. TGanz@mednet.ucla.edu

Abstract

The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.

[Indexed for MEDLINE]

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