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Biomarkers. 2010 Dec;15(8):715-30. doi: 10.3109/1354750X.2010.512091. Epub 2010 Oct 1.

Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers.

Author information

1
Research, Development & Engineering, Altria Client Services, Richmond, VA 23219, USA. Jeffery.S.Edmiston@altria.com

Abstract

BACKGROUND:

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.

OBJECTIVE:

To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD.

MATERIALS AND METHODS:

Random forest modelling and a split-sample case-control approach were used to identify candidate predictors.

RESULTS:

We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).

CONCLUSION:

These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease.

PMID:
20887155
DOI:
10.3109/1354750X.2010.512091
[Indexed for MEDLINE]

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