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Bioessays. 2010 Dec;32(12):1040-9. doi: 10.1002/bies.201000083. Epub 2010 Sep 30.

Mitochondrial manoeuvres: latest insights and hypotheses on mitochondrial partitioning during mitosis in Saccharomyces cerevisiae.

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Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.


Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for mitochondria and other organelles.

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