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Nat Rev Drug Discov. 2010 Oct;9(10):790-803. doi: 10.1038/nrd3253.

Microtubule-binding agents: a dynamic field of cancer therapeutics.

Author information

1
INSERM 590, Faculté Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France and Université Lyon 1, ISPB, Lyon, F-69003, France. charles.dumontet@chu-lyon.fr

Erratum in

  • Nat Rev Drug Discov. 2010 Nov;9(11):897.

Abstract

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an important therapeutic target in tumour cells. Agents that bind to microtubules have been part of the pharmacopoeia of anticancer therapy for decades and until the advent of targeted therapy, microtubules were the only alternative to DNA as a therapeutic target in cancer. The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties. In the current search for novel microtubule-binding agents, enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms are the three main objectives.

PMID:
20885410
PMCID:
PMC3194401
DOI:
10.1038/nrd3253
[Indexed for MEDLINE]
Free PMC Article

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