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Antiviral Res. 2010 Dec;88(3):281-6. doi: 10.1016/j.antiviral.2010.09.016. Epub 2010 Sep 29.

Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure.

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1
HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Abstract

Using quantitative deep HIV-1 sequencing in a subject who developed virological failure to deep salvage therapy with raltegravir, we found that most Q148R and N155H mutants detected at the time of virological failure originated from pre-existing minority Q148R and N155H variants through independent evolutionary clusters. Double 148R+N155H mutants were also detected in 1.7% of viruses at virological failure in association with E138K and/or G163R. Our findings illustrate the ability of HIV-1 to escape from suboptimal antiretroviral drug pressure through selection of pre-existing drug-resistant mutants, underscoring the importance of using fully active antiretroviral regimens to treat all HIV-1-infected subjects.

PMID:
20883724
DOI:
10.1016/j.antiviral.2010.09.016
[Indexed for MEDLINE]
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