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Ir J Med Sci. 2010 Dec;179(4):599-601. doi: 10.1007/s11845-010-0586-z. Epub 2010 Oct 1.

Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?

Author information

1
Department of Neurology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.

Abstract

Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.

PMID:
20882363
DOI:
10.1007/s11845-010-0586-z
[Indexed for MEDLINE]

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