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Leuk Res. 2011 Mar;35(3):363-8. doi: 10.1016/j.leukres.2010.08.010. Epub 2010 Sep 28.

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.

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1
IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy. giovannidarena@libero.it

Abstract

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

PMID:
20880586
DOI:
10.1016/j.leukres.2010.08.010
[Indexed for MEDLINE]
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