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J Comp Pathol. 2011 Feb-Apr;144(2-3):164-9. doi: 10.1016/j.jcpa.2010.08.008. Epub 2010 Sep 28.

Expression of multidrug resistance-associated P-glycoprotein in feline tumours.

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1
Department of Pathology, Bacteriology and Poultry Diseases, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. sara.vanderheyden@ugent.be

Abstract

Permeability glycoprotein (P-gp) is a membrane-bound efflux pump that mediates the active transmembrane transport of a variety of substrates. Several studies in human and canine normal and neoplastic tissues indicate that P-gp is involved in resistance to chemotherapy and in the development of multidrug resistance (MDR). The purpose of this study was to evaluate P-gp expression with the monoclonal antibody C494 in common feline tumours from 88 patients not pretreated with chemotherapy. Tumours arising from tissues with intrinsic P-gp expression consistently showed positive labelling for P-gp in a cellular pattern identical to that described for the normal feline tissues. Both P-gp positive and negative tumour cells, however, were found in mammary gland tumours, lymphomas, mastocytomas and squamous cell carcinomas. Feline mammary gland tumours in particular showed strong membranous P-gp labelling, especially in areas with infiltrative growth and atypical cells, although this was not correlated with the grade of malignancy. These findings might have implications for future response to chemotherapy.

PMID:
20880544
DOI:
10.1016/j.jcpa.2010.08.008
[Indexed for MEDLINE]
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