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4D computed tomography reconstruction from few-projection data via temporal non-local regularization.

Author information

1
Department of Radiation Oncology, University of California, San Diego, La Jolla, CA 92037-0843, USA.

Abstract

4D computed tomography (4D-CT) is an important modality in medical imaging due to its ability to resolve patient anatomy motion in each respiratory phase. Conventionally 4D-CT is accomplished by performing the reconstruction for each phase independently as in a CT reconstruction problem. We propose a new 4D-CT reconstruction algorithm that explicitly takes into account the temporal regularization in a non-local fashion. By imposing a regularization of a temporal non-local means (TNLM) form, 4D-CT images at all phases can be reconstructed simultaneously based on extremely under-sampled x-ray projections. Our algorithm is validated in one digital NCAT thorax phantom and two real patient cases. It is found that our TNLM algorithm is capable of reconstructing the 4D-CT images with great accuracy. The experiments also show that our approach outperforms standard 4D-CT reconstruction methods with spatial regularization of total variation or tight frames.

PMID:
20879225
[Indexed for MEDLINE]

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